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Dr. David Haase is the founder and President of the MaxWell Clinic. He is passionate about finding and addressing the complex underlying causes of disease and thereby nurturing the Creation of Health. His expertise touches a wide range of specialties from personalized computational systems medicine, brain performance optimization and more. Dr. Haase is also the author of the best selling book Curiosity Heals The Human.

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Here’s a glimpse of what you’ll learn: 

  • Dr. Haase talks about methylation and its importance
  • What is methylation? 
  • How does methylation occur in the body
  • Dr. Haase talks about Randy Jirtle and his experiment with agouti yellow mice
  • The role of methylation in preventing DNA damage
  • What molecules get methylated in the body and how methylation helps in the body detoxification process
  • Dr. Haase talks about the molecule S-adenosylmethionine (SAMe) and its role in methylation
  • How methyltransferase shepherds SAMe
  • How SAMe is used and studied for certain health conditions
  • Why SAMe supplements are more expensive
  • Dr. Haase explains why the intake method of SAMe matters
  • What you need to expect when doing nutritional interventions
  • The importance of knowing how your SAMe supplement was sourced, made, stored, and delivered.
  • The role that SAMe plays in the treatment of fatty liver disease
  • Dr. Haase discusses a study where SAMe was used as a treatment for liver cirrhosis
  • Dr. Haase talks about the role of SAMe in the production of the body’s master antioxidant: glutathione
  • The importance of sticking to methylation in relation to your biochemistry
  • How SAMe can affect neurodegeneration
  • The role of SAMe in our body’s viral defense systems
  • How to increase the effectiveness of your recharging of SAMe
  • Things you need to ask yourself when you want to create health for yourself
  • The product Dr. Haase formulated that has SAMe and trimethylglycine
  • Why Dr. Haase is cautious about bipolarism
  • Why a good diet is enough to give you the methyl products you need for your body
  • How to connect with Dr. David Haase

In this episode…

In the field of human healthcare, it is not uncommon to see doctors change their minds about how to best treat diseases. As they continue to test, learn, and study new ways of using specific vitamins, enzymes, or molecules in treating certain diseases, they delve even deeper into the vast and complex biochemistry of the human body especially since each person’s genetic makeup is unique and could require a more specific method of treatment. And for Dr. David Haase, one of the body processes that has fascinated him and the whole of the healthcare industry is the process of methylation.  But what is methylation? How do you induce it and what are the things you need for your body to maximise the benefits of methylation? Does the wonder molecular S-adenosylmethionine or SAMe really an important factor in this process? Does the understanding of both the molecule and the process really play a big role in designing the optimal health plan for yourself? In this episode of Super Humanizing, Dr. David Haase discusses the truth about methylation, the common misconceptions about it, and the supplement that will help you get the most out of this process that can help you live a healthier life. Stay tuned.

Resources Mentioned on this episode

Sponsor for this episode

This episode was brought to you by CreatingHealth.com. Creating Health is a movement that was started in order to tackle today’s medical challenges and the way that people look at disease. At CreatingHealth.com, you’ll also find a collection of nutritional supplements that Dr. Haase has formulated over the years. They were manufactured with the highest standards of quality, and all have been formulated with my own patients in mind.  The website is also a great place to get scientific information about supplements. On each page where a supplement is featured, you will find research about all the compounds used in it.

Episode Transcript  

Dr. David Haase  0:00   Hello, I’m Dr. David Haase. And this is Superhumanizing, where we explore the human condition, and how it can be better for each individual person. As a physician who sat knee to knee with thousands of patients, I’m convinced that each person’s potential for bing a better version of themselves is just a bit of knowledge or a few new tools away. Over the years, I’ve grown more and more frustrated by not having the time with each individual patient to fully dig into the topics that I knew would help them the most. on this show, you get to sit in on my conversations with some of the greatest experts in today’s healthcare revolution. Doctors, researchers and entrepreneurs who are looking beyond the brute force suppression of symptoms to discover and address the underlying root causes of sickness and dysfunction. So please join the conversation by following me on Facebook or Twitter at David Haase, MD. To learn more, visit DavidHaaseMD.com, where you can subscribe to my mailing list and be the first to know about important developments in this exciting world of systems medicine. And with that,   Dr. David Haase  1:10   please enjoy today’s episode of super humanizing.   Dr. David Haase 1:15   This is   Dr. David Haase  1:17   our methylation versus methylation installment to hear the creating health podcast. I’m Dr. David halsy. And I’m here to take you through the rambling thoughts of my brain as I’d love to be able to communicate them in full to my patients, many times I’m sitting knee to knee with a patient and we’re looking over these complex lab results. And I love to be able to go into all the detail that I want them to understand, and that I find so incredibly fascinating and cool. And they’ve spent over 20 years accumulating in the realm of systems and metabolic medicine and, and it just don’t have time. So this is the time to do that. We’re going to dive into a topic that I just find out absolutely fascinating. And it’s fascinating on a social level on a cultural level and metabolic level, on a psychological level. Yeah, you’ll get the point. I, I enjoy complex systems, you know, all too often, we try to boil down a topic into a soundbite. And, and you know, marketing is right behind it as soon as that’s being done, right. I mean, I’ll many times that we’ve been taken down this path of making something overly simple so that it sticks in our brain like an earworm. And as soon as we feel like we understand something, we develop a comfort level around it. And that comfort level says, I’m not an idiot. But I am actually smart and useful and, and anyway, it no longer hurts our brain to think about something once we feel like we’ve made a decision on it. And so often in the realm of medicine, we Grab onto more simplistic ideas just because they’re highly comfortable. And we need an answer. And people are often very frustrated with the field of human healthcare because you’re thinking doctors keep changing their mind about what the answer is, as we continue to absorb more scientific inquiry and data. But you know, that’s the way it is. That’s reality. Reality is insanely complex. And what we’re trying to do is to hack reality, understand reality, so that we can improve human health and disease. And then we’re going to go into a topic about methylation today, and methylation is astoundingly important. astoundingly underrated and astoundingly overrated all at the same time. So what brought me to bring this topic up? I’m sitting with one of my patients and and I said, you know, it’s it’s very clear by metabolic studies that you have a challenge with methylation, and he said what methylation and and it struck me I was like, Wait a second, this actually that’s a better term, its methylation like mythology. Because what is a mythology? and mythology is a story that we make up to explain something that’s beyond our understanding. You know, there’s that you’re the in ancient times and even modern times we make up stories to help assuage our brains need to, to understand to feel like we have a handle on the challenges are in front of us that this amazingly complex, natural world thrust upon us so we make a story up about oh, that’s why this happens. You know, this is where you go to your horoscope and you say,   Unknown Speaker  4:54   you know,   Dr. David Haase  4:57   Mercury’s in retrograde and that’s why everything bad is happening. me right now. And to the extent that these mythologies are useful, awesome, so since they’re not harming anybody awesome, but when I heard this person say, Is this a mythology, for me is this methylation rather than methylation? I knew that he was onto something. So let’s go into this. So, methylation, if you kind of haven’t been on the internet has become a topic that’s become very popular, especially in the natural health world. What is methylation? a methyl group is a single carbon atom. And whenever a single carbon atom, which if it’s a alcohol, we call it methanol. If it’s a pure hydrocarbon, you know that’s that is a methyl group. And if we’re if it’s a So it’s a single carbon group yo that is being attached to something we say that is the process of methyl lation. And many different molecules are built by the addition of another carbon molecule we are based off of organic chemistry, which is really the study of the organization of carbon based life forms. So adding on a single carbon onto another molecule is super fundamental in the process of life in general. So, methylation is the addition of a single carbon group on to another molecule.   Unknown Speaker  6:41   And in the body. This happens   Dr. David Haase  6:44   in many different forms in many different ways. There’s enzymes which are chemical machines that control when this single carbon atom is attached on to another molecule. We call those methyl transferases. So it’s a a molecule that transfers the methyl group. And they’re highly specific, specific. So when we talk about methylation, that’s kind of a general concept, but in the world of life in the world of physiology, methylation is highly controlled by these individual methylation enzymes, so that we can put an extra carbon group on a histone, which is what we wrap our DNA around, or we can put an extra methyl group on histamine to detoxify it, or we can put us and that would be a histamine methyl transferase. Or we can add a methyl group to adrenaline. And that would be the enzyme co methyl transferase. Are we like I said, if we put a methyl group on a histone, that would be a DNA methyl transferase. And so it’s not just the the is not just a This is happening willy nilly that there’s a soup that’s being stirred together. The addition of a carbon atom on to another molecule is a highly specific thing. Now who the heck cares? Well, the reason should care is that depression, osteoarthritis, virus viral disease, cirrhosis, heart disease, dementia, all of these have very clear associations with our the process of methylation. And in there are ways that we’re able to build methyl groups or remove methyl groups. And it’s exceedingly important understand, but the, it was hilarious when the guy said, Well, this is a myth, you know, a, I get my words even mixed up on this like I do a few methyl groups. But this is a mythology.   Unknown Speaker  8:55   Hey, and   Dr. David Haase  8:57   because in about 2000 Oh no, maybe nine 2008 there became a a rising, understanding one particular gene called mthfr. mthfr is one of the major genes that’s, that is responsible for helping produce the methyl groups that the body needs in order to be able to do the work of methylation, and almost became a mini cult around this gene. And in understanding what is your mthfr status, started to be applied to virtually everything under the sun, every condition, everything was explained by Oh, it’s mthfr. And that’s what it really started to become really more of a methylation process. And so many fads go yo this became wildly popular, and then over the course of time as more data was known, and more experienced, The leaders of that trend started to back off a bit and recognize a know there’s a whole lot more involved than just the having the right kind of B vitamin involved to to assuage this molecular soup. And so instead, now we’re actually at a point where we can embrace this methylation experience and start to inquire How can it actually improve human health?   Unknown Speaker  10:27   So some of   Dr. David Haase  10:30   this came up with a meeting I had with Randy jirtle. Randy is really that I think kind of the founder in many ways of nutra. genomics, the effect of nutrition on genetic expression, especially as we understand epigenetics. I met Randy at a meeting a couple of weeks ago, we had a discussion. And he was the guy who did the famous agouti mice six mouse experiment. Now, the agouti mouse is an interesting mouse and they’re sitting studying the effects of plasticizers especially BPA on how these particular mice behave, what happens in the womb of such mice when they are actually exposed to BPA and BPA? For those of you who aren’t aren’t aware or don’t recall, you know, is a toxin that is present in the lining of, of cans. It’s certainly in the plastics that are rather credible, or I should we say flexible, because plastic in its pure form is very rigid. You put impurities and one of these impurities is Bisphenol A, and a lot of press about how bad it is, you know, for our bodies. And our parents medical note, just getting something BPA free doesn’t solve you, because there’s a BP, BP and BBC and BP nbp there’s a massive class of these molecules. So just stay away from eating from plastic if you don’t want the substances in your body. So, rainy journal did this fascinating study on agouti mice. And they gave a group of these mice BPA, and the more BPA they gave, the more it messed up their methylation. And and so this caused the mice with messed up methylation to have to change actually the color of their code to have increased breast and prostate cancer, decreased reproductive function, and very substantial obesity. And then what was found is that if you gave these same mice, methyl eaters, you’ll be 12 full late, Sammy, you’re able to reverse this process and actually take the These mice, you know, that had been made to be fat and cancerous and sterile or, or decrease fertility least, and transform them back with a nutritional intervention was absolutely astounding. Now why is that? Because methylation is one of the major ways that we actually prevent our DNA from being damaged. DNA gets wrapped around a histone. Think of this like a packing tool. And the DNA that’s wrapped around the histones largely protected from the ravages of the world, from oxidative stress and from chemical injury. And in order for this histone rapping to occur, or in order for certain genes to be turned off, a single methyl group is put on something called a CPG Island and that Basically shuts off that gene for a period of time, which is very important if that gene happens to be one that allows the progression of cancer. So keeping certain genes quiet is exceedingly important. Now, when we think of this methylation process, and knowing that you could dramatically change actually the long term output of multiple generations of mice, it makes us aware that this is an underlying process of adding a single carbon group on to other molecules is is something that we need to pay attention to.   Unknown Speaker  14:41   And so   Dr. David Haase  14:42   that’s why I want to dive into more deeply. What is methylation and how can we control it and how can we modify it? So let’s first of all, think about some of these molecules that get methylated Well, you heard of many of them. melatonin for instance, in order to make melatonin in the body, serotonin actually has to be methylated and Wallah that starts to control not just sleep but a whole host of other hormonal functions that melatonin governs. How about epinephrine or epinephrine requires methylation. So that’s one of our major adrenaline stress hormones, without appropriate methylation, hard to make. co q 10 is a molecule exceedingly important in energy production in the body, and it exists in the inner membrane of the mitochondria. Oh, we’re going to talk a lot about mitochondria on this podcast because I it’s been something I’ve been teaching about for over 15 years and, and something is so central to health. So look for more of information on mitochondria coming up. But co q 10 is a molecule super important in mitochondria to decrease oxidative stress and it requires methyl elation in order to be formed. How about the cell wall itself the cell wall is made up of we call festival libbets. And those are a couple of fats attached to a phosphate group that and in order to make phosphatidylcholine, the major fat that is present in all that makes up all of our cell walls it takes guess what methylation to occur along with the ability to make carnitine which is important for the production of muscle and creatine. Again for the shemin currenty is important for the transference of fats inside the mitochondria so that we can burn energy and creatine, creatine. You know, you hear about creatine being added to drinks muscle builders will consume because it will bump up the ability to make muscle guess what you need methylation to make creative RNA and DNA are methylated. The detoxification of many molecules requires methylation, especially estrogens. And arsenic. arsenic goes from a very toxic compound we call inorganic arsenic to becoming organic at arsenic by the, by the addition of three separate methyl groups. Then the year, we can go on and on and on, because of course, methylation is the foundation of organic biochemistry, because organic biochemistry is the study of molecules with a carbon skeleton. So this is the fundamental building block and why it’s so important, and also why it’s tightly controlled. And there’s so many nuances to how this works in the system. I think it’s you cannot really start a conversation about methylation, without talking about the V molecule That does methylation. And a lot of attention is given to methylfolate and methyl be 12. And trying up a glycine there. So when we go to those, but there’s one molecule, there’s actually the methyl later and that’s called s adenosine on the fighting, or Sam, he, Sam, he is what we should be focusing on in understanding how methylation works. Sammy, is actually a medication in Europe called Adam at. It is used widely for the treatment of depression. And it is a remarkable molecule as is we’re going to spend most of our time talking about here, because in order to make Sam he which is a an amino acid called the file name, that gets attached to an energy molecule called ATP. Now most people have heard of ATP, because it is the energy currency of every cell in the body. Every cell requires ATP in order to do every single function. Matter of fact, your body makes your entire body weight equivalent of ATP every day and uses the equivalent of your body weight of ATP every day. It is energy currency. And it makes most reactions occur. ATP is generated in the mitochondria. So if your mitochondria are really sick, you have a hard time making ATP.   Unknown Speaker  19:30   So if you have a hard time making ATP,   Dr. David Haase  19:33   because of metabolic challenges to your mitochondria, or oxidative stress, or all the kind of things that will go into as we talk about mitochondrial health, you’re going to have a difficult time making Sammy. Because remember, Sammy is ATP plus refining. And refining is an amino acid that bears a sulfur group you always know sulfurs around because it kind of stinks. And sulfur. And that’s why selter is also central in this whole process of methylation, sulfur, and carbon tend to travel together in these metabolic pathways. And we’ll know more about that because this whole pathway also attaches to our body’s ability to make glue to phone, which is our body’s master antioxidant. And that is based off of sulfur. So it’s so beautiful. We have this big map up in our clinic. It’s right right now we have one that’s six foot by eight foot long and I’m trying to get one about 12 to 10 foot. That’s just an entire metabolic map of physiology. And when you go up and you trace where a molecule is coming from and going to and you recognize that is it, it is attached to not just one or two other endpoints, but rather it’s it is connected like a web to the entire rest of metallic mentalism gives you such a beautiful sense of all about metabolism, how every system has almost every system has several backup systems. And I think that’s where the mythology of methylation goes wrong. Many times when people have find an answer, they think it is the answer. But as we found in, in addressing understanding of how these methyl groups are important in human health, it’s not as simple as giving more vitamins. It’s not as simple in any way shape or form because of the complexity of regulation. So let’s come back here. So we’re talking about what is the methyl later and that is Sam e s, adenosine refining. It is the universal donor of a single carbon group. And when the single carbon group gets it attached to norepinephrine to make epinephrine. You’re left with the breakdown product called homocysteine. So homocysteine, you actually goes through s adenosine, homocysteine and your homocysteine breaks down homocysteine but you’re there a lot of details that I love that maybe you don’t so I’m trying to make a little simpler but as we get the breakdown product of Sammy is homocysteine that lets you know methylation has happened, methylation has been completed, and then homocysteine needs to get recycled back into refining, in order to become Sammy in order to methylate in order to become acidosis homocysteine back to homocysteine. So it is this methylation cycle that occurs and there’s a couple of different ways that homocysteine becomes Mathias and again, and that has a lot to do with our methylated, phalates and methyl Be 12 and even a compound called tri methyl glycine.   And so there’s that is the that is the SAM II methylation cycle. But the really the whole point of it is to make Sammy so that you can do the job of methylation. And that job of methylation is then controlled by these various methyl transferases. Remember, you can only have Sammy if you have enough ATP. So you gotta have the math dynein plus ATP to make Sammy. Sammy is then shepherded by the methyl transferases. We’ve talked about a couple of those already, you know, so for instance, the DNA methyl transferase, you know, which have several different types of protect DNA. This is actually probably why green tea is protective against cancer. Many studies showing that consumption of green tea decreases cancer incidence in the long run. And that has everything to do with the shaping of the expression of DNA methyl transferases by one of the compounds in green tea called egcg. Also available in supplementation form. But there’s also methyl transfer aces that control the production I mentioned of melatonin that would be called hydroxy indle or methyl transferase. And then there’s histone methyl transferase, which controls which genes are turned on, in which genes are turned on. There’s phospho title ethanol amine methyl transferase, and that controls the production of phosphatidylcholine which is your cell membranes. So you see it just keeps the rabbit hole is huge. And the methyl transferases are really the stars. So and knowing how which ones of those are turned on. doing their job is really where the science will continue to go. Just having enough methyl groups around. That’s just the beginning of the conversation. But how we shape various methyl transferase activities is really where the science is going.   Unknown Speaker  25:16   So So   Dr. David Haase  25:18   yeah, just cool. So this is why our diet is so incredibly important because it’s not just giving us methyl groups. It’s also shaping which methyl transferases are turned on. So let’s talk about a couple is diamond is Sam he a little bit more because I just love Sammy. You know, it has been studied as a drug for many different conditions, especially in Europe, and in and there’s actually been double blind placebo controlled trials that have looked at it in comparison with emit bromine and emit bromine is thought to be a gold standard, try cyclic antidepressant, it’s one of the old school antidepressant caused a lot of side effects, but also was pretty darn effective, one of the more effective antidepressants, and it turned out that 1600 milligrams of a pill form of Sammy turned out to be equivalent 150 milligrams of emit bromine study published in 2002, in the American Journal of Clinical Nutrition. And I think that’s, that’s quite remarkable when we think, hmm, just by the addition of this pre form methylation molecule, they’re able to clinically change the pathway of depression meaningfully. Now, why might that be so you already mentioned that this process of methylation has a tremendous amount to do with neurotransmitter activity. And, and so, in order to make many of our neurotransmitters it requires the process of of methylation. So, certainly the production of dopa mean production of serotonin and the production of norepinephrine and all have components that involve the availability of methylfolate. So,   Unknown Speaker  27:22   so astounding.   Dr. David Haase  27:24   Now the, the study also showed that Sammy was actually effective at 400 milligrams if it was injected, and so 5400 milligrams injectable versus 1600 milligrams as an oral tablet. So it’s all about bioavailability How can you get a high blood level of Sam e so that you can have the effective outcome? Nice study that was done also published in the American Journal of Psychiatry, a major US journal, that the Sami Given twice a day, was able to dramatically change and improve the effect of SSRIs. In the treatment of depression. In this one, they use 800 milligrams of an of an oral tablet form of Sammy, which will tell you why that may not be the best way in a bit, but 800 milligrams twice a day had caused nearly 46% of these prior non responders to an SSRI to respond, you know, 46 versus 17% for the placebo. And that means there’s really only a number needed to treat a three so three people need to be treated for one person to gain benefit again, and you know, there’s no these are individuals who weren’t tested. They they, their metabolism wasn’t checked to see if they were actually deficient in methylation products. There wasn’t genetic analysis done They were they were just given a diagnosis of depression because they presented with the symptoms of depression. I think we do much better when we’re targeting individual metabolic intervention based upon lab work that would suggest this individual needs Sammy more than another individual so but still wow you know, depression is horrific for not just the individuals who have the problem but all family members that are associated. And so you know, anything that can help improve the dramatic symptoms of depression in a way that has low downside, I think should be embraced, embraced. Now, what’s, what’s interesting is, you know, some mouse studies done that you’re thinking about Sammy doesn’t actually directly make serotonin However, when Sammy was injected into mice. They saw the serotonin go up in the hippocampus nearly 300% after just one hour. Now, why is this important, but because the hippocampus is one of our major areas that we see degeneration with, as it revolves around Alzheimer’s disease, and in this hippocampus has a lot to do with neuro plasticity of the making of new connections. And when we when we examine some of the effects of the SSRI medications, and those would be like sertraline, or fluoxetine, or brand names such as Zoloft and Prozac, some of the biological effects that we observe them having us they after about six weeks, they cause new neurons to be sprouting. And we think that’s part of the reason of the effectiveness when they’re effective for people. And here is so that Sammy was able to cause some of that same up regulation of serotonin And that is associated with hippocampal neurons sprouting, that is, again associated with the time course symptom improvement in depression. So it’s notable that the effect of Sammy is actually the PhD faster than antidepressants. And it can be rare. It’s incredibly useful. Now, I mentioned a little bit about administration. I think I’ll just dive into that first, because I mentioned blood levels seem to be highly related to outcome. And Sammy is a very fragile molecule. I mean, it is the energy molecule ATP plus this single carbon atom. It’s very reactive. it decays quickly whenever exposed to light, to humidity, to oxygen, and so it needs to be protected and it’s manufacturers very tricky. It’s It’s what we call an extension. molecule because it’s hard to make, it’s hard to purify. It’s hard to keep it stable. So it’s almost always one of the, it’s always more expensive as a supplement goes and some other vitamins that are, are much more stable. And so   the idea of how do you get more bang for your buck is actually a really important question. And there’s a form of Sammy that I’m very familiar with, which is an orally absorbing form of Sammy. This is a company you can put this under the tongue in a powder. In Europe, there’s a tablet that can slowly absorbed and we will see blood levels of CME go up and not equivalent of an injection, but substantially more than what you get from a enteric coated capsule and let’s just make sense. Then you take a Sami pill, and if you take a Sami pill, it needs to be in a little packet individually packet ID, preferably those packets filled with nitrogen gas and opaque so light can’t come through. In Do you want to really protect your CME capsules wherever you get them and then put a Sammy capsule when taken or tablet will should be coated so it gets past all that acid that’s in the stomach and it opens up in the small bell. And then the Sammy is going to actually interplay with the bacteria that are in your gut, and you’re going to that capsule is going to deliver a lot of Sammy to the bacteria. Some is going to make it to the cells that are lining the inside of the gut wall. And then some is going to be brought up through the portal vein and into the liver. And you’re going to get a substantial amount of Sammy in the liver. So if you’re treating something that’s a liver problem, you know, and maybe the enteric coated Sammy capsule is actually the right choice. But if instead you’re what you’re trying to do is get a high level of Sammy in the bloodstream. So you can get it to the joint so you can get it to the brain. So you can get it elsewhere in the body, in orally absorbing form a CMD gives a higher blood level. And, and I in and anecdotally, in practice, we’ve noticed that people have to take less from a molecule molecule base to get better effect. So, really, how you take it does matter.   Unknown Speaker  34:31   And so   Dr. David Haase  34:32   one other point is I’ve mentioned this a very fragile molecule.   Unknown Speaker  34:35   molecules, you know, they’re so tiny, they’re so tiny, they’re so cute.   Dr. David Haase  34:43   But in order to describe how they are actually shaped, which is where they draw their power, we have to use all kinds of fancy designations and, and one is to talk about in antium, or immerse and then team or is it the direction of a bond. So, the active form of Sam he is something we call it we recognize is that it is in an S s in antium or state. And this s s enantiomer is the active form of Sammy. When it’s exposed to a little bit of light, when it’s exposed to a little bit of heat, it degrades into an R s form of Sammy. And the problem with an RS form of Sammy is that it literally blocks the effects of the s s form of the the active form of Sammy   Unknown Speaker  35:41   and so   Dr. David Haase  35:43   it inhibits methyl transferase reactions. Now, this was brilliantly described in shown in a study when they were comparing Sammy versus Sela Cox’s which is Celebrex for the treatment. osteoarthritis oh my gosh and we a second we just talked about depression being useful in depression. And now I am talking about osteoarthritis What the heck. And so they compared it to both Celebrex and relevant and they were able to show that it had equivalent equivalent improvement to Celebrex with substantially fewer side effects. But this study that was done. This was published in the British Medical Journal of musculoskeletal disorders in 2004 or they did a double blind randomized placebo crossover trial between Sammy and Sela Coxon. Now that’s a really well done conventional drug trial. structure you know it is it is going to say All right, we’re going to give people are going to say okay, you get Celebrex and you get some Me. And now we’re going to track you. We’re not gonna tell you who got what. And then we’re gonna have a washout period of time where you’re either not going to get anything, and then we’re going to switch it. And whoever got Celebrex before it’s gonna get Sammy in the second half of the study and the converse those that got Sam, you then got Celebrex an amazing thing happened. So as they gave, they were there were equivalent dosing. So from the start of the trial to the first endpoint, which was at two months there they would they had exactly the same amount of knee pain decrease. Now, we know that the drugs that shut off, Cox has an enzyme which is what celac coxa does. You can have a very quick response to decreasing inflammation and decreasing pain. So I think it’s really useful that they put the Time course at two months or these individuals,   Unknown Speaker  38:03   because   Dr. David Haase  38:05   that’s how nutrition works. If you want to do nutritional interventions, you shouldn’t expect the same kind of time course that a well dosed poison will give you and that’s what drugs are. And drugs are well dose poisons, they, they’re anti this, their inhibitor that their blocker of their just look at the names of the drugs, it’s actually very evident that these are well dosed poisons, and we so we selectively and carefully poison certain pathways in the body to decrease symptoms. Now, I don’t necessarily think that’s the best way to go. If there’s a way that we can restore a higher level of function and thereby decrease the symptom that almost always has less side effects. And I think that’s what this study really helped us see. So So if we look at these individuals or two months period of time, and actually the effect was already a one month But persisted to two months that the Sammy and Celebrex did just great. Then they flipped the individuals, they flipped the study and did the crossover part of the study. And the individuals they were taking Sammy now actually started to do worse than the individuals that got Celebrex. And the study organizers were really sharp, they did something that I have a tremendous amount of respect for. And they were curious by the results. And and so they actually it was about 75% of the way through the study, this routine quality check that they built into the study and showed that the study medicine, Sammy had lost about 51% of its potency, because just opening the bottle, just just having Sammy exposed at all will cause it to degrade rapidly over 51% of its potency. was lost that means there was more of this r s in antium er than the s s enantiomer. And therefore, then the study was delayed until a new batch of Sami could be obtained. And then it was continued. And then again, after it was continued with fresh Sammy wala, the same studies are the same outcome occurred. So it’s very important when you’re looking for a form of Sammy to take that, you know, where is it coming from, you know, what was its producer, you know, the raw material supplier that’s probably the best in the world is a company called nosis. And they’re out of Milan, Italy, and they’re just super high quality producer and then how was it manufactured? You know, what it should be manufactured and played in a manufacturing plant that can provide a very low humidity environment that is also a low light environment. That oxygen levels can be controlled. It’s a fragile molecule because you want the end product to have over 70% of the sanny that’s in that product be the SS isomer. So, yeah, some nerdy details but a lot of times you’re like, Oh, I took Sammy it didn’t do anything for me. Well, did you take an active form just start out to be active. Did it age did it we taking in a way that actually got to the tissue of incidence and and even more importantly, did you need it in the first place? Where you just so I think this is you know, the details are so fascinating and important. When you think of how am I going to improve the health of my body is bringing this nutritional component into my body going to be of benefit. There’s there are details That are important. Now, Sammy, you think, Okay, well, we’ve kind of covered depression. And you know, we’ve talked a bit about its utility in osteoarthritis. Is it good for anything else? Well, so another interesting study looking at Seattle hepatitis, so this would be fatty liver disease. And what’s interesting is that in fatty liver,   Unknown Speaker  42:30   you   Dr. David Haase  42:32   this low Sammy contributes to a low mitochondrial ghouta file and level. And it also contributes to a low phosphatidylcholine to ethanol neom ratio. So the ability of the mitochondria and the membranes of the liver to make the membranes that they need and to maintain this fluid membrane has a lot to do with Sammy availability. What we know about fatty liver disease is it’s all Most always tied to mitochondrial dysfunction and low ATP stores make for low, Sammy, low, Sammy causes these membranes to get stiff, and it can contribute to that eventual fat accumulation, as many of the things that help with fatty liver are definitely helping to improve the health of mitochondria and thereby help the process of methylation. So   Unknown Speaker  43:30   it’s it’s really very interesting that   Dr. David Haase  43:35   you can see this restoration of the membrane fluidity of liver cells with Sammy, but you don’t see that same change happen with an acetylcysteine, which is a common precursor to help you make more gluta found it very helpful for living in SEO cysteine is very helpful. all kinds of other things over 600 studies on and acetal cysteine, which I think deserves a whole podcast onto itself, that it’s cheap, it’s safe. You Tiffany, lots of utility in the world. But I give that little preamble that to think that Oh, Sammy is actually important in the treatment of fatty liver disease, to talk about this study. Now, this is a study I think that ethically there’s a problem in the world that we haven’t seen this either replicated and disproven, or replicated and proven and its results implemented. And this is studying Sammy in the treatment of liver cirrhosis. And this is a blip wrote in 1999. A good study was done randomized, placebo controlled double blind multicenter clinical trial 123. People with alcoholic cirrhosis were randomly assigned to either get 1200 milligrams of an oral intemperate coded Sammy placebo for two years. So good long term study every time you’re looking at a nutritional study. You know, if it’s not a long term study, it’s probably not giving you data that’s meaningful, because, you know, nutrition just doesn’t work fast. That’s been my experience. I think this is one of our problems. When we think of the studies that are looking at omega three fatty acids or vitamins or minerals, we really need to take a much longer view in understanding the utility of nutritional supplementation to help human health but I digress. So let’s come back to alcoholic liver cirrhosis. People die from this, this causes a substantial number of deaths and a lot of transplants. So, you know, and I don’t know about you. I have seen a lot of people with liver transplants. I was at the Mayo Clinic I trained at the Mayo Clinic. I worked in the liver transplant Ward One of the saddest and most challenging medical environments that I have ever been exposed to, because when an individual first of all needs a liver transplant they become incredibly ill leading up to that point nine, you know, their, their liver is not making what it needs for life to exist, therefore, they either get a liver transplant or they die. So these are not well people to start with. And then after a liver transplant occurs and that liver hasn’t yet kicked into play. The body can’t make coagulation factors. It can’t make albumin it can’t make so many of the factors necessary for life that these individuals end up getting hundreds of units of plasma and   Unknown Speaker  46:50   coagulation factors and   Dr. David Haase  46:52   transfusions and it is a it was one of those complex difficult conditions to treat and even it may clinic where I really believe the best medicine in the world happens. We just had an incredibly hard time managing these very sick patients. So anything that we can do to decrease the number of transplants that are necessary, and also to decrease the deaths of those people who didn’t even make it the transplant. I think it’s a moral imperative that when you hear the study when you hear the results of these this study, I want you to think is we have a moral problem that we haven’t seen this replicated yet and I’ll be glad to help and talk to anybody who has the funding to do so or could you facilitate this process?   Unknown Speaker  47:43   Because   Dr. David Haase  47:44   in the individuals given Sammy a, you know, 1200 milligrams of Sammy for two years, Sammy, cause that advanced liver disease to be cut in half. So the liver transplants rate, we’re 30% for the placebo versus 16% for the sandy supplemented group. So we have, you know, P value of 0.07. So, that wasn’t, it was a small study. So the p value wasn’t as as low as we want it to be looking at statistical significance, but but absolutely worthy of more study. But here’s the interesting thing, if we excluded advanced liver disease at the beginning of the trial, and we looked instead at those, the mild liver disease, the results were 29% needing liver transplant, versus 12% needing liver transplant, not just that, Sammy also decrease the mortality of the individuals with alcoholic cirrhosis compared to placebo. So we’re seeing a decrease of mortality, a decrease of liver transplant rates when given a nutritional supplement for two years. Wow. And why? Because you’re helping these mitochondria to function and work better to help them recover. And then the next thing, so, so Wow, I just give me chills every time I think about that and the power of this molecule the power of methylation, as as transmitted through the methylating molecule Sammy, and how what effect that can have on human health and disease. But what’s also interesting to note, right, these are chronic alcoholics. They did not come into this process. Quickly, this was a chronic toxic poisoning. And, and Sammy also has the ability when you take it acutely and I happen to be known to hand out little packets of orally absorbing Sammy when I’m partying with my friends as I take this at the end of the night because me turns up the enzymes that will decrease that will start the will accelerate the breakdown of alcohol, it will up regulate alcohol dehydrogenase and aldehyde dehydrogenase by by two to 300% within two to three hours. And that’s a huge amount of up regulation of the enzymes necessary for the detoxification of alcohol. So in these patients that are alcoholic, they are injuring their mitochondria. So they can’t make Sammy. They don’t have Sammy, they can’t turn on as effectively the enzymes that detoxify alcohol, and it leads to a feed forward cycle. So you know, I believe in better living through chemistry, right. And so, if Sammy can decrease the toxicity of alcohol, I think we need longer and larger studies to take a look at these facts always we need more data, but man is a safe me It certainly be a safe insurance policy. seed to have at the end of the night. Of note. It has been noted that individuals that take Sammy at the beginning of an evening I give them a little sachet of Sammy with recharge factor. They, they say it’s hard to get a bus. So I would recommend that particular intervention lifestyle intervention to be taken at the end of an evening of frivolity as opposed to at the beginning. So keep down the cost of drinks. So,   other things about Sammy, so Sammy does this other remarkable thing is it turns on an enzyme that is actually important for the production of gluta file, include a phone is the body’s master antioxidant. So this is an enzyme called Sif, the thigh on beta synthase, or CBS and I mentioned that there’s kind of a mythology around methylation and you know, when I With 23andme came out, people could finally start seeing their genetics, it more cost advantageous method and started doing the analysis. There’s programs that you can take your genetics through and say, Oh, these are my methylation genes. And this is what this is, what is our single nucleotide polymorphisms, which mean, these are the common variants in the population that I have, or the metabolism of full eight and B 12. And that is wonderful if those things are causing health, health and health for individuals. I bless them, I am so glad that that is helping where it is helping. But I have witness so too often that people start to look at their genes like their destiny, as opposed to kind of a metabolic suggestion, which is really what they are. It’s so much more important to look at your actual biochemistry because your biochemistry is really The interplay of your entire environment plus all of your genes, looking at single nucleotide polymorphisms, like mthfr, and CBS and NTR and there’s a whole alphabet soup out there around the world of methylation. And some people treat this almost like a religion long diatribes online saying oh you have this this low and this is high and this is this therefore you can only take this supplement you can only eat this food and, and you can only do it you know, a full moon and and again, I am just attached to results. The results are the only thing that matter in my clinical philosophy. It’s not about being right. It’s about being useful. And if the if what is being done is helping and useful Glory Hallelujah. But when people self styled experts or individuals who want to get a lot of blog hits, make very strong statements about this is the right way and this is the wrong way. I can guarantee you that they’re wrong. Because the body is complex and most all genetic manifestations are poly genetic means we need to take into account a whole host of genes, often hundreds, sometimes thousands of genes to help understand the process. And those genes actually only control the world based upon the environment that they are exposed to. So this is where you need to battle methylation and stick with methylation. And be curious about what’s going on in your biochemistry. You know, I measure things like homocysteine or, or methylmalonic acid or there’s organic acid analyses. There’s a whole bunch of ways to look at this if there is a problem. But don’t just buy into the fact that because you have a particular gene uniqueness, that you are destined for particular gene outcome I went on that diatribe because of this gene called sit the thigh on beta synthase. Remember back in the day when I was talking about this, Sammy cycle, Sammy becoming accidental homocysteine becoming homocysteine. then going back up to my finding and becoming Sammy again. Well, homocysteine, although it’s a breakdown product, and I like to call it kind of like a Brillo pad in the arteries, I mean, homocysteine has some nasty associations along with it. That we see higher depression depression is two times higher in individuals with high homocysteine than low homocysteine. And in when methyl groups are given, you know, five methyl full weight is given to those individuals that they preferentially respond with an improvement in mood. blood levels actually also raise homocysteine is not just a full late problem, but it’s It’s a problem with the environment and toxicity in general.   It the homocysteine actually messes with these DNA methyl transferases you know, the enzymes I talked about that are going to shepherd where the individual fully or the individual carbon group gets attached. Well guess what homocysteine messes with that process messes with the methylation of genes. And therefore, is that may be one of the ways and how it functions. So, the short term studies looking at be 12 and full eight and be six in the treatment of high homocysteine to decrease coronary artery disease have been really disappointing. You know, we although those those nutrients that actually decreased homocysteine, they actually haven’t decreased cardiovascular disease in the present studies. I think that’s because homocysteine is not just pointing to those a problem with methylation There’s an underlying toxicity that homocysteine is pointing to that we need to continue to be curious about. Curious. So a little plug for my book I wrote a book called curiosity heals the human because I this is a great point, like, well, if these B B vitamins weren’t that that did decrease homocysteine weren’t enough to drastically decrease our heart disease. Well, what’s going on? How can we be curious because there still is a very tight Association. The same high homocysteine is more associated with neurodegenerative disease and the be 12 and fully be six probably have more of a importance in that group. So I have interest and homocysteine because it’s a breakdown product of Sammy. You’ll see people on the blogosphere you’ll say, Oh my gosh, you can’t take Sammy because that breaks down into homocysteine. homocysteine is bad. No, no, no know it you know in a study done at Mayo Clinic, they gave 800 milligrams of of Sammy a day to patients and so absolutely no elevation of homocysteine they didn’t see a small decrease in cholesterol however, Isn’t that fascinating? Ah the got to add cholesterol to this list of a fascinating effects. Right.   Unknown Speaker  58:24   And,   Dr. David Haase  58:26   and then, but what about if you give methylfolate methylfolate will actually raise Sammy, or she just give me if you give Sammy, you’ll actually raise your level of methylfolate that’s available, which is one of the other components of this full late cycle. It does seem to be that health supports health and not in a way that you’re giving natural molecules doesn’t seem to have as much detriment because the body has such a complex metabolism. There are ways to adapt around. There are always exceptions and doses do matter. But in general, working with the body with with original manufacturers replacement parts, you know, tremendously helpful, tremendously helpful. So, Sammy will actually help you make glue to file and glue the thigh own is your body’s master antioxidant. It’s also helps you detoxify nasty molecules and having enough glue to fire and enables your mitochondria to function well. So if you have enough, say me, it helps make lucify own, which helps the mitochondria work better, which helps you make more Sammy. So I like this because I always think the mark of a really great therapy is that the longer you use it, the less you need it. You know, are you actually able to help reset a function in the body so that you can attain that longer term higher level of health. You know, that’s what we would say it’s creating health. You’re not just treating a disease. And one of the reasons I love Sammy because I see there many of these different tendrils that if we can get this Sammy level, elevated and supported in a person’s body, that gives the individual opportunity to heal so they don’t need to keep taking the Sammy, which I think is reasonable. Now, you may need to take Sammy for several years. let’s not let’s remember we’re talking about a nutritional timescale, not a drug timescale. But, but astounding. So, I did mention a bit about Alzheimer’s disease. If you would look at the cerebral spinal fluid level of Sam e. in the in the US, if you’re looking at that level, Sammy in the actual CSF, which is the fluid that surrounds the brain and the spinal cord, you’ll find that it’s substantially less in individuals with Depression and dementia. And by giving Sammy, you’re actually able to raise that level in the individuals with depression and dementia. DNA hypo methylation is an along with its high homocysteine is actually associated with the overexpression of the enzymes that make em beta amyloid. So beta amyloid is one of the Oh, you may not be fire but it’s at least smoke for all timers disease. It’s a marker of Alzheimer’s disease and it certainly it perpetuates an ongoing brain degeneration.   Unknown Speaker  1:01:46   And some of these genes that   Dr. David Haase  1:01:48   have over have control over the process of neuro degeneration in any all timers that they have the young version, at least Certainly are affected by the level of Sammy. What happens if you give Sam he two mouse timers sufferers? Yes, mouse timers? How do we study this long term neurodegenerative process? You know, we use animal models that can mimic somewhat the same factors. If you give mice that are affected by Alzheimer’s CME, they actually have less than beta amyloid production. They have improved spatial memory. They have inhibited induction of these pro Alzheimer’s genes. There’s decreased phosphoric ization of tau which is a, an aggregate that occurs inside the cells of individuals affected with Alzheimer’s disease, and is one of the feed forward mechanisms that caused problems in in the brain and neurodegenerative And there’s even reduced plaque spreading. And this is even an individuals who got enough who already had enough B vitamins around. So they were in animals were given plenty of B vitamins that are B vitamins sufficient not beat up vitamin deficient, not be vitamin deficient. And they were given additional Sammy. And there was still improvement in the reduction of plaque spreading pretty astounding stuff. And so down seal refining really helps prevent oxidative stress and improves gluta file and metabolism in these mice. So we see with gluta found in the same mouth simers model, increase the superoxide dismutase. This is one of the enzymes that does our anti oxidation that cleans up the sweat and smoke of metabolism. There’s a decrease in Liquid peroxides which are one of the burned fats that occur from oxidative stress,   Unknown Speaker  1:04:06   and   Dr. David Haase  1:04:08   it increases glutathione transferase activity, you know, which takes this Master detoxifier antioxidant and attaches it on to toxic molecules to to remove those molecules. And it also improves the ratio of the active form of Bluetooth ion to the, we call it the reduced form of Bluetooth ion which is the enact or the oxidized form of Bluetooth ion which is the inactive version. So, Sammy has a markable multifactorial effect on the amount and the effectiveness of Bluetooth ion present in these mice with Alzheimer’s. Now, we do see some of those same effects in human studies. But we’re not able to take a look at what actually happens in the brains of humans. It’s hard to get people to sign up for that study. You know Then Sammy also has evidence for, you know, association with our entire viral defense systems. So before we had these remarkable drugs for hepatitis C, you know, we Sammy was investigated as a Agilent therapy with interferons. And and it was shown that there’s nearly twice the viral decline in individuals that were given Sammy, along with the standard, you know, anti viral therapy. So, you know, this is kind of gets a little crazy, doesn’t it? And, and it’s actually impossible to understand all of these changes. If you don’t actually understand that methylation is a universal process that goes on in biochemistry and that universal process and biochemistry governs, you know, a host of different end outcomes in the body. I think that’s what’s so important to recognize. We’re not a we’re not a linear organisms, we exist in complexity, we in the net makes treatment of us as remarkably complex individuals challenging sometimes, because the simple answer may not be the sufficient answer. What we may need to do is continue to be curious and find that what is the right question that is going to help us actually improve the outcomes that we want to have in our life?   Unknown Speaker  1:06:42   So   Dr. David Haase  1:06:44   you know, so that is, you know, my diatribe into Stan, he turns out and, and I, and this Sammy is also let me take a couple more things about how to actually increase the effectiveness of your recharging of Sammy Because Sammy, like I said, it’s an expensive molecule monetarily. And it’s also expensive for the body to make metabolically. It takes a lot of resources because you have to make ATP. And every time you make them a molecule of Sammy, you’re using up an ATP molecule that could be used for something else.   Unknown Speaker  1:07:19   So   Dr. David Haase  1:07:20   we want to make sure that we’re efficient with our production and utilization of Sammy.   Unknown Speaker  1:07:25   So this,   Dr. David Haase  1:07:26   let’s think about the recharge a factor of how do we get from homocysteine back up to my fining? Because that’s a very critical step. And that is actually where you’re taking homocysteine and you’re adding the methyl group on to the homocysteine. And then that’s what is then met finding here that the term change though, the meth and there’s two main pathways to get from homocysteine to refining one of them is through the foliate pathway, and this is using   Unknown Speaker  1:08:05   method using a gene that takes   Dr. David Haase  1:08:10   in uses b 12. And methylfolate as well as vitamin B six is kind of a cofactor. In that is one method of conversion. So many of the drugs that have been used to stimulate methylation are based around methylfolate. And actually quite high doses of methylfolate have been shown to decrease the level of depression individuals that are already treated with SSRI medications. And so it can actually be used as a drug to push the level of methyl push the level of maligning that’s being produced. But the other form the other way that you can get there is through a compound called tri methyl glycine and try methyl glycine or another As beltane will uses a bypass loop to convert homocysteine to refining. And many studies are recognizing that this blend of Sam e plus tri methyl glycine increases the the often times the amount of Sammy that’s available in a very effective way. This tri methyl glycine or is actually able to kind of rescue the methylfolate that is available to the body. And it’s been used in the treatment of fatty liver disease, for protection from alcohol toxicity. There’s even some really interesting studies that go back to the 1950s to promote cardiac health and to promote into support the production of cell membranes. Now I think most of These effects are because this tri methyl glycine, or what I like to call recharge factor, is actually able to recharge Sammy to do all these things. It is a it’s a great, safe and stable nutritional supply for full aid. Anyway, I want to really encourage you, you know, allow this wonder that is metabolism, you know, to cause joy in your heart. Your body is created in a way that it’s designed to create health. It’s designed to adapt. When it’s beset with challenges, it figures a way around those challenges. But sometimes the way it figures its way around that challenge is actually what produces the disease. So, when we’re thinking of creating health, we want to ask ourselves a question so what may be missing in my Life that, if added in could enable my body to create health more effectively, or what barriers present that if I could remove from my body would enable my body to create health at the level that of which it has potential. And it’s really remarkable. It’s so encouraging because we have this capacity. Sammy is one great example of the power of nutritional therapies. And most people don’t have any idea how much science is out there because this is not a patentable molecule. And that’s a problem because you can’t really find money from private industry that wants to put the effort into doing the studies to gain conventional indications like you would with a typical drug. You really want instead to have a you would like to government research to increase on this And we’d like to be able to have better answers for these therapies that have very low side effects. So Oh, Ms. A word about side effects. Again, the internet has been fascinating. I’ve been utilized. And I had my mthfr genetics done way back in 2002. Way before some of what are the luminaries of methylation had even entered the field yet. And mthfr became a real interest of mine because I happen to possess some of those polymorphisms where, you know, understanding and utilizing these nutritional therapies is a good thing for me and my brain and the rest of my body. So, I became intensely interested because of my own challenges in this field. You know, gosh, you know, getting to be almost two decades ago now. And as we as we dive into and are asking questions about this field,   Every time we think we have an answer, it does produce two more questions. So the longer you do this, the more you start focusing on the big picture. How do we understand humans in their complexity? And, and that’s one of the challenges with nutritional science is that we can try this one molecule in this group of patients, but how do we define which group of patients we’re actually going to study? If we study individuals with depression? Well, guess what? There’s a lot of reasons to be depressed other than a methylation defect. Their problem Oh, and we’re going to a bunch of that in future podcasts on the, you know, electro physiologic abnormalities and metabolic abnormalities and psychologic and trauma. I mean, there’s a whole host of reasons why, but when individuals are well selected, and we have investigated deeply as What is your personal kryptonite, you know high may you have the challenges you have that come out in symptoms that are not specific, then we have an opportunity to make a lot better advances in health care. So, even as we asked for more study and want more study, looking at particular in stage conditions, we have to also recognize that those studies are necessarily going to be challenging to do because we’re studying highly complex humans that have multifactorial problems that require multifactorial interventions, to really bring us to the point of health and happiness. And   Unknown Speaker  1:14:46   so   Dr. David Haase  1:14:47   this part of the reason I love this field is that there’s never going to be an end to questions. There’s never going to be an end of possibilities to explore. And at the same time, we can see very meaningful, real benefit. fit in people   Unknown Speaker  1:15:01   you know, one of the   Dr. David Haase  1:15:04   you know I actually formulated a product that is Sammy plus this recharge factor which is trying methyl glycine. And, and it was my formulated it because I want to assure that it was coming from the best source of production in the world that it was produced in a facility that was custom designed to produce and handle Sammy in order to maintain a really high SS to Rs ratio. And then to blend that Sammy 400 milligrams of have a very specific form of Sammy with tri methyl glycine so that it was possible to get more bang for your buck metabolically and in observing the effectiveness in patients. It’s been really very rewarding to see how this formulation has has helped patients with various states have a methylation challenge. Now, this particular formulation is hilarious, because I always have to coach people on actually how to take it. It comes in a little stick pack, and it’s designed to be orally absorbed. And this oral absorption it’s made into a powder that’s very tart. So I always ask people if they like like lemon drops or tart foods, because if they really can’t stand sour, it’s going to be hard for them to take this. But if they do, you take this little stick pack and open up the top and dust just a little bit of this Sammy and try methyl glycine, dust under the tongue and slowly allow it to absorb and then wait wait a minute or two until it’s all gone and then put a little bit more in sometimes it takes about five minutes, I think to take one of these stick packs of Sammy and trim up the glycine well so it absorbs herbs into the tissue under the tongue. So it’s able to, you know, just have it orally be available in that way some of course are going to is going to be swallowed. And then what’s fascinating is we did blood levels, I work with Baylor College of Medicine in sub sent, freeze dried, you know, a sense samples under dry ice conditions to the metabolic lab to see, you know, where we actually going to get an increase in blood levels. And, and quite remarkably, I was very surprised with how the blood levels of Sammy were able to increase from baseline with this oral administration. So, again, always need more studies always need more data to understand what is going to work best in home. I typically prefer using these early absorbable forums. for things that are going to treat the body as a whole, the brain, the joints, you know the immune system. But if I want to help treat the liver or address a liver condition in a patient of mine, I’ll prefer a an orally or a internet coated capsule that I think will actually produce a higher dose level in the Oregon that we’re targeting. So being rational about this is the best that we can do until we have good comparative data. But I think to not take action in using a substance that is so incredibly safe, but just really be ashame as well. I meant I was starting go off on the blogosphere a bit. But one of the things that comes up and people are worried about having Sammy causing this It and that has not been the case in my practice at all, especially before the blogosphere started up. It’s actually the the the side effect profile of Sammy is incredibly benign, in all of the a very extensive published literature that has come out of Europe. For this particular product, anxiety, depression, all of those are minimal. There’s some gi upset, occasionally the individuals getting a headache, but that’s less than 1% of the population. I’m always cautious with bipolar disorder. I think bipolar disorder is we have we need to have a podcast and bipolar disorder because I think that the understanding that condition differently can help   increase the level of freedom people experience in their life. In short, bipolar is really an irritable brain. You know, it is A brain that has suffered a lot of inflammation and oxidative stress. And, and Sammy may be helpful in those cases. But anything I mean, I always tell my patients with bipolar this anything can cause can purportedly cause a manic episode or a bipolar break to occur that’s been shown with the vitamins that’s been shown with Sammy is shown up not at all it’s been shown with broccoli. It’s been shown with, you know, tomato extracts, it’s been shown, you know, there’s virtually everything that changes the function of the brain could be purported to exacerbate a bipolar episode, but the the actual it’s never been. I think there’s one case study of that being documented. But I still always encourage go low, go slow, make sure that the fundamentals of health and well being are being taken care of For one dives into a supplement, and maybe somebody should have said first that, you know, where do we get these methyl products? Where do we get full aids in our diet? Where do we get coline in our diet, all these methyl donors while we get them in our diet, right? These don’t have to come packaged in some bottle or or sashay. This is very much diet related in full eight comes in very large amounts in leafy green vegetables. And when has that been a bad thing? Very rare, but those are actually a problem food in people’s lives. So more leafy green vegetables are a great way to increase the most natural form of full weight that’s available to the human.   Unknown Speaker  1:21:45   And then   Unknown Speaker  1:21:49   if we   Dr. David Haase  1:21:49   go a little deeper and start thinking about the 12, although that’s basically from animal sources, very high level levels and liver in the muscles tissue of animals. So individuals with there’s very strict vegans should monitor their b 12 status. very strongly consider taking b 12 supplementation if you’re vegan. And then coline is President very high amounts in eggs. You know, phosphatidylcholine is one of the major preformed compounds that are in egg yolks. And quite helpful. So there are many different sources, but I always encourage a very high quality organic whole food diet that is going to support not just methylation, but support the processes that cause the body to have a methylation need in the first place. The more inflammation, the more more inflammation the more oxidation the more methylation need is going to be there. So it’s always recognizing the person is Whole and recognizing that our goal is to create health by the safest mechanisms possible. And in so it’s my life’s passion.   Unknown Speaker  1:23:12   Normally I, you know,   Dr. David Haase  1:23:14   I only have these discussions with patients and then they’re actually quite abbreviated but this passion of education of giving people a larger view into the world of nutrition, health disease, creating health, dementia, is it this is this is a joy. And it’s been great to be with you. If you have any questions, so we have a couple of websites. Creating health com is a supplement apothecary that has the Sammy plus recharge factor available. Our clinic is Maxwell clinic. We’re based out of Nashville, Tennessee, and we’re very interested in addressing the underlying causes of illness diving deep in too, why health and disease, maybe it’s expressing itself in individual persons, and we love to be a service. We’re very thankful to get to spend this time with you. And until next time, continue to create health every day. Take care of Dr. David Ozzy. If you’ve made it this far, you’re a curious person. And if you’re curious, you probably have questions. And if you have questions, my type of audience, so to ask those questions, while using email, when you can put it somewhere the whole community can see, after all, you never know what bit of information may end up improving someone’s life. If not saving it. Just head over to Facebook or Twitter and post your question. If you tag me at David halsy. md, and use the hashtag super humanizing. I’ll do my best to answer it, and then share it on my own page where everyone can discuss it. Please keep in mind that I’m only one person So I may not get to every question but your questions are very important to me, and I’ll always do my best to answer as many as I can. If you want to learn more about my clinical practice in the Nashville area, go to Maxwell clinic calm. To browse the hundred plus supplements I’ve formulated for my patients over the years. Visit creating health com. You can get a copy of my book, watch some videos or listen to more of this podcast by heading over to DavidHaaseMD. com. There you’ll be able to subscribe to my mailing list and receive up to date information on regenerative plasma exchange and systems medicine approaches for dementia. Thanks for listening